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Dons et mécénat

L'Institut de Recherche en Hématologie et Transplantation (IRHT) depuis 20 ans des travaux sur les cellules souches dans le traitement des leucémies, cancers et, très récemment, de l’infarctus du myocarde.

Nos recherches ont abouti sur des avancées thérapeutiques spectaculaires qui sont toujours appliquées en priorité aux malades de notre région…

Publications

Identification and isolation from either adult human bone marrow or G-CSF-mobilized peripheral blood of CD34+/CD133+/CXCRA+/Lin-CD45- cells, featuring morphological, molecular, and phenotypic characteristics of very small embryonic-like (VSEL) stem cells. Sovalat H, Scrofani M, Eidenschenk A, Pasquet S, Rimelen V, Hénon P. Experimental Hematology (2011) Vol. 39, 494-505,

Développements actuels de la Thérapie Cellulaire dans le cadre des syndromes ischémiques cardiovasculaires

Hénon P, Pasquet-Vallejo S, Sovalat H. Angeiologie, 2011, Vol. 63, N°2

Taxonimical classification of hematopoietic CD34+ cells subsets from diverse origin

Matuszewski R, Sovalat H. Studies in logic, grammar and rethoric 21 (34) 2010

Long-term benefit of intra-cardiac delivery of autologous G-CSF-mobilized blood CD34+ cells containing cardiac progenitors on regional heart structure and function after myocardial infarct.

Pasquet S, Sovalat H, Bischoff N, Hénon Ph., Arkam Y, Ojeda-Uribe M, Le Bouar R, Rimelen V, Brink I, Dallemand R, Monassier J-P. 2009. Cytotherapy (2009) Vol. 11, No. 8, 1002-1015

Three-dimensional distribution patterns of CD34 antigen on nonactivated cord blood cells.
Jung G, Wunder E, Dieterlen A, Hénon P, Jacquey S. Cytometry A. 2008 Jan;73(1):16-21

TEF-1 dependent expression of the alpha-tropomyosin gene in the three muscle cell types, J. Biol. Chem. 281 : 34406-20.

Pasquet S, Naye F, Faucheux C, Bronchain O, Chesneau A, Thiebaud P and Theze N, 2006

Relative quantification of residual tumor cells by lightcycler real-time IgH PCR in autografted multiple myeloma patients.

Rimelen V, Ferrand C, Debecker A, Sovalat H, Tancredi C, Eidenschenk A Hénon P. Leukemia. 2005 Mar;19(3):492-5.

Peripheral blood and BM CD34+ CD38- cells show better resistance to cryopreservation than CD34+ CD38+ cells in autologous stem cell transplantation.

Ojeda-Uribe M, Sovalat H, Bourderont D, Brunot A, Marr A, Lewandowski H, Chabouté V, Peter P, Hénon P. Cytotherapy. 2004;6(6):571-83

CD34+ cells and CD34+CD38- subset from mobilized blood show different patterns of adhesion molecules compared to those from steady-state blood, bone marrow, and cord blood.

Sovalat H, Racadot E, Ojeda-Uribe M, Lewandowski H, Chabouté V, Hénon P. J Hematother Stem Cell Res. 2003 Oct;12(5):473-89.

Importance of CD34+ cell subsets in autologous PBSC transplantation: the mulhouse experience using CD34+CD38- cells as predictive tool for hematopoietic engraftment.

Hénon P, Sovalat H, Bouderont D. J Biol Regul Homeost Agents. 2001 Jan-Mar;15(1):62-7. Review.

Improvement of clonality detection rate in multiple myeloma using fluorescent IgH PCR with different sets of primers.

Welterlin V, Debecker A, Tschieb D, Zanetti C, Lange W, Hénon P. J Hematother Stem Cell Res. 2000 Dec;9(6):983-91.

Human accessory cells have a humoral bystander effect on CAFC growing on murine feeder.

Mazini L, Wunder E, Sovalat H, Jung G, Bourderont D, Bachorz J, Bearenzung M, Zanetti C, Hénon P. J Hematother Stem Cell Res. 2000 Oct;9(5):749-57.

Role of the CD34+ 38- cells in posttransplant hematopoietic recovery.

Hénon P, Sovalat H, Bourderont D, Ojeda-Uribe M, Arkam Y, Wunder E, Raidot JP, Husseini F, Audhuy B. Stem Cells. 1998;16 Suppl 1:113-22.

Primordial role of CD34+ 38- cells in early and late trilineage haemopoietic engraftment after autologous blood cell transplantation.

Hénon P, Sovalat H, Becker M, Arkam Y, Ojeda-Uribe M, Raidot JP, Husseini F, Wunder E, Bourderont D, Audhuy B. Br J Haematol. 1998 Nov;103(2):568-81. Erratum in: Br J Haematol 1999 Jul;106(1):264. Bouderont D [corrected to Bourderont D].

Comparative analysis of class I, II and III epitope-detecting CD34 monoclonal antibodies by quantitative flow cytometry.

Sovalat H, Racadot E, Hénon P, Fuchs P Lewandowski H, Billot M.

Hematol Cell Ther. 1998 Dec;40(6):259-68.

Mature accessory cells influence long-term growth of human hematopoietic progenitors on a murine stromal cell feeder layer.

Mazini L, Wunder E, Sovalat H, Bourderont D, Bearenzung M, Bachorz J, Hénon P. Stem Cells. 1998;16(6):404-12.